OrbiMed Advisors

Superinvestor profile · Rank #94 by reported 13F value (2026 Q2 filers) · CIK 0001055951 · All profiles
Founded 1989New York, New York, U.S.Healthcare-dedicated investing across public equity, private equity and royalty/creditKey person: Sam Isaly
Reported 13F value
$5.4B
Period 2026-06-30 · Filed 2026-08-14
Positions
129
Top 10 = 42.1% of value
Clone CAGR (full window)
+5.6%
2016-11-14 → 2026-10-02 · cumulative +72%
SPY CAGR (same window)
+15.5%
Cumulative +316%
Max drawdown (monthly)
-48%
Month-end values, approximate
Latest-quarter activity
42 new · 25 exited
32 increased · 27 decreased
Hypothetical clone — not this fund's returns. The performance on this page replicates only the long U.S. equity positions disclosed on this manager's Form 13F filings, rebalanced on filing dates at disclosed weights with dividend-adjusted prices. It excludes shorts, bonds, cash, non-U.S. listings, private holdings, leverage and fees. Treat it as a measure of how the disclosed stock picks performed, never as the fund's track record. Evidence: filing-by-filing dossier (PDF) · Methodology (PDF)

Clone performance

2016 2026 — 13F clone — S&P 500 (SPY)
WindowClone CAGRNote
Full window (2016-11-14 → 2026-10-02, 40 filings)+5.63%Cumulative +71.8% vs SPY +316.1%
Trailing 10Y—
Trailing 5Y+1.00%
Trailing 3Y+13.61%
Trailing 1Y+11.84%

Top holdings — 2026 Q2 filing

TickerCompanyWeightReported value
EWTXEdgewise Therapeutics Inc11.68%$631M
ELVNEnliven Therapeutics Inc6.37%$344M
LLYEli Lilly & Co5.73%$309M
MBXMbx Biosciences Inc3.51%$189M
SVASinovac Biotech Ltd3.42%$184M
AZNAstrazeneca Plc3.17%$171M
GPCRStructure Therapeutics Inc2.20%$119M
SIONSionna Therapeutics Inc2.08%$112M
CRVSCorvus Pharmaceuticals Inc1.98%$107M
AVBPArrivent Biopharma Inc1.95%$105M

As reported on the 2026-06-30 Form 13F (filed 2026-08-14). Full holdings and quarter changes: holdings page.

Filing history in this profile

Every clone input traces to one of these SEC filings. 73.8% of the latest filing's reported value is covered by our price history; the remainder is mostly non-U.S. listings, recent IPOs or delisted names and is excluded from the clone.

QuarterSEC accession no.FiledDisclosed CUSIPs
2026Q20001172661-26-0037402026-08-14117
2026Q10001172661-26-0023692026-05-15105
2025Q40001172661-26-0011192026-02-17104
2025Q30001172661-25-0050472025-11-1498
2025Q20001172661-25-0035142025-08-1497
2025Q10001172661-25-0023552025-05-15106
2024Q40001172661-25-0011362025-02-14111
2024Q30001172661-24-0051672024-11-14109
2024Q20001172661-24-0035392024-08-14108
2024Q10001172661-24-0025062024-05-15112
2023Q40001172661-24-0014612024-02-14109
2023Q30001172661-23-0040192023-11-14120
2023Q20001172661-23-0031772023-08-14118
2023Q10001172661-23-0023232023-05-15114
2022Q40001172661-23-0013102023-02-14112
2022Q30001172661-22-0025532022-11-14126
2022Q20001172661-22-0019982022-08-15134
2022Q10001172661-22-0014562022-05-16137
2021Q40001172661-22-0007952022-02-14155
2021Q30001172661-21-0023322021-11-15166
2021Q20001172661-21-0018412021-08-16153
2021Q10001172661-21-0013452021-05-17152
2020Q40001172661-21-0007862021-02-16146
2020Q30001172661-20-0022952020-11-16140
2020Q20001172661-20-0018592020-08-14131
2020Q10001172661-20-0014072020-05-15138
2019Q40001172661-20-0008592020-02-14132
2019Q30001172661-19-0023522019-11-14108
2019Q20001172661-19-0018832019-08-14119
2019Q10001172661-19-0013822019-05-15116
2018Q40001172661-19-0008682019-02-14123
2018Q30001172661-18-0021682018-11-14140
2018Q20001172661-18-0016602018-08-14134
2018Q10001172661-18-0012392018-05-15124
2017Q40001172661-18-0007952018-02-14123
2017Q30001172661-17-0021462017-11-14129
2017Q20001172661-17-0016992017-08-14125
2017Q10001172661-17-0012162017-05-15124
2016Q40001172661-17-0007662017-02-14118
2016Q30001172661-16-0043182016-11-14125

Background (founded / HQ / style) source: https://www.insidermonkey.com/hedge-fund/orbimed+advisors/254 — Founded in 1989 in New York by Sam Isaly, originating from Mehta and Isaly; Isaly now serves as Chairman Emeritus. One of the world's largest dedicated healthcare investment firms.